Table 3.

PET Tracer Uptake by Region of Interest

PIB DVR		LPA (N=3)*	PNFA (N=6)		SD (N=5)		AD (N=10)	CONT (N=12)
		PIB-Pos (3)	PIB-Pos (1)	PIB-Neg (5)	PIB-Pos (1)	PIB-Neg (4)	PIB-Pos (10)	PIB-Neg (12)
Whole Cortex	L	2.16 ± 0.08	1.90	1.31 ± 0.07	2.39	1.19 ± 0.09	2.04 ± 0.09	1.31 ± 0.03
	R	2.10 ± 0.10	1.96	1.35 ± 0.09	2.34	1.20 ± 0.10	1.99 ± 0.09	1.30 ± 0.03
	LI	0.03 ± 0.01	−0.03	−0.03 ± 0.05	0.02	0.00 ± 0.04	0.03 ± 0.04	0.01 ± 0.02
PPA ROIs
Frontal	L	2.31 ± 0.06	1.86	1.34 ± 0.09	2.42	1.23 ± 0.15	2.11 ± 0.26	1.39 ± 0.10
	R	2.19 ± 0.06	1.89	1.40 ± 0.09	2.31	1.18 ± 0.17	1.99 ± 0.38	1.38 ± 0.11
	LI	0.05 ± 0.02	−0.02	−0.05 ± 0.07	0.05	0.04 ± 0.13	0.07 ± 0.09a	0.00 ± 0.06
AntTemporal	L	1.59 ± 0.08	1.49	1.28 ± 0.12	1.33	0.94 ± 0.13	1.65 ± 0.16	1.29 ± 0.06
	R	1.62 ± 0.05	1.57	1.33 ± 0.12	1.43	1.11 ± 0.05	1.53 ± 0.19	1.27 ± 0.06
	LI	−0.02 ± 0.04	−0.06	−0.04 ± 0.04	−0.07	−0.17 ± 0.11	0.08 ± 0.07a	0.02 ± 0.06
TemporoParietal	L	2.57 ± 0.15	2.24	1.35 ± 0.10	2.52	1.25 ± 0.17	2.09 ± 0.57	1.36 ± 0.09
	R	2.38 ± 0.06	2.12	1.37 ± 0.16	2.50	1.18 ± 0.12	2.11 ± 0.45	1.37 ± 0.09
	LI	0.07 ± 0.04	0.05	−0.01 ± 0.10	0.01	0.05 ± 0.08	−0.03 ± 0.11	−0.01 ± 0.10
Cumulative PPA	L	2.16 ± 0.12	1.86	1.33 ± 0.08	2.09	1.14 ± 0.12	1.95 ± 0.29	1.34 ± 0.05
	R	2.06 ± 0.08	1.86	1.37 ± 0.10	2.08	1.16 ± 0.10	1.88 ± 0.31	1.34 ± 0.06
	LI	0.04 ± 0.01a	0.00	−0.03 ± 0.04	0.00	−0.03 ± 0.05	0.04 ± 0.06	0.00 ± 0.03
Hippocampus	B	1.22 ± 0.06	1.12	1.16 ± 0.06	1.18	1.01 ± 0.06	1.27 ± 0.07	1.19 ± 0.06
Norm FDG		LPA (N=4)	PNFA (N=5)		SD (N=5)		AD (N=10)	CONT (N=12)
		PIB-Pos (4)	PIB-Pos (1)	PIB-Neg (4)	PIB-Pos (1)	PIB-Neg (4)	PIB-Pos (10)	PIB-Neg (12)
Whole Cortex	L	2.07 ± 0.29	2.05	2.12 ± 0.13	2.21	1.87 ± 0.16	1.81 ± 0.26	2.07 ± 0.14
	R	2.24 ± 0.27	2.04	2.18 ± 0.10	2.31	1.91 ± 0.08	1.86 ± 0.25	2.06 ± 0.13
	LI	−0.08 ± 0.03a	0.01	−0.03 ± 0.03	−0.04	−0.02 ± 0.07	−0.03 ± 0.03a	0.00 ± 0.02
PPA ROIs
Frontal	L	2.25 ± 0.48	2.18	2.26 ± 0.21	2.62	1.98 ± 0.30	2.09 ± 0.38	2.46 ± 0.21
	R	2.47 ± 0.53	2.32	2.39 ± 0.19	2.67	2.16 ± 0.10	2.08 ± 0.32	2.33 ± 0.18
	LI	−0.12 ± 0.06a	−0.06	−0.06 ± 0.08	−0.02	−0.10 ± 0.18	0.00 ± 0.09	0.06 ± 0.06
AntTemporal	L	1.55 ± 0.13	1.46	1.47 ± 0.12	1.08	1.16 ± 0.30	1.34 ± 0.15	1.53 ± 0.10
	R	1.66 ± 0.20	1.39	1.53 ± 0.14	1.30	1.25 ± 0.09	1.34 ± 0.17	1.55 ± 0.15
	LI	−0.11 ± 0.06a	0.04	−0.04 ± 0.05	−0.19	−0.10 ± 0.23	0.00 ± 0.07	−0.01 ± 0.08
TemporoParietal	L	1.89 ± 0.44	2.36	2.48 ± 0.35	2.40	1.99 ± 0.19	1.70 ± 0.45	2.33 ± 0.18
	R	2.17 ± 0.32	2.46	2.38 ± 0.23	2.42	2.07 ± 0.18	1.85 ± 0.49	2.39 ± 0.21
	LI	−0.16 ± 0.12	−0.04	0.03 ± 0.07	−0.01	−0.05 ± 0.04	−0.08 ± 0.08a	−0.02 ± 0.04
Cumulative PPA	L	1.88 ± 0.28	2.00	2.07 ± 0.17	2.03	1.71 ± 0.10	1.71 ± 0.30	2.11 ± 0.13
	R	2.10 ± 0.28	2.06	2.10 ± 0.14	2.13	1.83 ± 0.05	1.76 ± 0.30	2.09 ± 0.14
	LI	−0.13 ± 0.05a	−0.03	−0.02 ± 0.06	−0.05	−0.07 ± 0.07	−0.02 ± 0.05	0.01 ± 0.04
Hippocampus	B	1.29 ± 0.11	1.15	1.23 ± 0.08	1.02	0.98 ± 0.03b	1.06 ± 0.07b	1.28 ± 0.06

^*- One study excluded due to motion artifact.

^a- Significantly different than 0 (p<0.05).

^bSignificantly lower than LPA, PNFA and controls (p<0.005). Values are means ± standard deviations. PIB DVR = PIB distribution volume ratio with cerebellar reference; Norm FDG = FDG uptake normalized to pons; LPA = logopenic aphasia; PNFA = progressive non-fluent aphasia; SD = semantic dementia; AD = Alzheimer’s disease; CONT = controls; L = left; R = right; B = bilateral; LI = lateralization index; AntTemporal = anterior temporal.