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Widespread induction of PCNA and virtual absence of cleaved caspase 3 in raft cultures harboring the wild-type or E6*I mutant plasmid. IHC was conducted to detect PCNA (left column) or the cleaved caspase 3 (right column) in day-16 raft cultures of PHK transfected with the wild-type HPV-18 (top row) or the HPV-18 E6*I mutant (bottom row). The small dots in cornified layers represent parakeratosis.
