FIG. 3.

Alendronate prevents glucocorticoid-induced cancellous and cortical osteocyte and osteoblast apoptosis in Cx43^fl/− but not in Cx43^{ΔOb−Ot/−} mice lacking Cx43 in osteocytes and osteoblasts. Mice were treated with daily alendronate injections, starting 3 days before pellet implantation. Twenty-eight days after pellet implantation, mice were killed, and apoptosis was determined. pred, prednisolone; n.s., not significant. ^a p < 0.05 by generalized linear models, n = 4–9 mice.