Table 2.
The top 14 cellular and regulatory pathways deemed to be most relevant to mucosal injury from anticancer therapy.
| Rank | Chemoradiation (Sonis, et al.) | Irinotecan (Bowen, et al.) |
|---|---|---|
| 1 | Toll-like receptor signalling | MAPK signalling |
| 2 | NF-kB signalling | Cell cycle |
| 3 | B-cell receptor signalling | Complement and coagulation cascades |
| 4 | PI3K/AKT signalling | Gap junction |
| 5 | Cell cycle | Calcium signalling |
| 6 | P38 MAPK signalling | Apoptosis |
| 7 | Wnt/B-catenin signalling | Leukocyte transendothelium migration |
| 8 | Glutamate receptor signalling | VEGF signalling |
| 9 | Integrin signalling | Cytokine-cytokine receptor interaction |
| 10 | VEGF signalling | Neuroactive ligand-receptor interaction |
| 11 | IL-6 signalling | Wnt signalling |
| 12 | Death receptor signalling | B cell receptor signalling |
| 13 | SAPK/JNK signalling | T cell receptor signalling |
| 14 | T-cell receptor signalling | Focal adhesion |