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. 2009 Feb 15;23(4):496–511. doi: 10.1101/gad.1775409

Figure 4.

Figure 4.

The life span of rict-1 mutants is highly responsive to diet, unlike wild type. (A) Median life span of rict-1 mutants is reduced 24%–43% on OP50 relative to wild type (N2). (B) While HB101 versus OP50 had marginal (13%) impact on wild-type life span, HB101 extended rict-1 (mg450) life span by 75%. In a repeat experiment (Supplemental Fig. S5A), life span impacts were −13% and 54%, respectively. (C) HB101 versus OP50 diet had a similar impact on rict-1(mg451), increasing life span by 75%, and in a repeat experiment (Supplemental Fig. S5B) by 74%. (D,E) Similar to HB101, feeding the K12 derived strain E. coli HT115 had insignificant (2%) impact on wild-type life span versus OP50, whereas for rict-1 (mg450) (D) and rict-1 (mg451) (E), life span increased by 71% and 76%, respectively. (F) Changes in diet affect Gompertz parameters for wild type but not life span, because a higher rate of aging is coupled with lower initial mortality; in contrast, rict-1 mutants have higher rates of aging at comparable initial mortality on OP50 versus HB101 and HT115. Error bars ±SD. (Gray diagonals) Lines of constant life span calculated assuming zero accident rate. Legend for F as in B–E.