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A Kaplan-Meier analysis of survival in male Agtr1a–/– animals and wild-type littermates is shown (log-rank test, 20.32; P < 0.0001 versus wild-type mice). The average life span of Agtr1a–/– animals and wild-type littermates was 31.20 ± 2.31 and 24.81 ± 3.10 months, respectively.
