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. 2009 Feb 2;119(3):573–581. doi: 10.1172/JCI37048

Figure 3. High-fat diet shifts the intracellular redox environment to a more oxidized state in skeletal muscle.

Figure 3

(A and B) SS31 prevents the increase in GSSG and decrease in GSH/GSSG ratio in response to acute glucose ingestion. GSSG content (A) and GSH/GSSG ratio (B) were measured before (–) and 1 hour after (+) oral glucose ingestion in red gastrocnemius muscle of rats (10-hour-fasted) fed standard chow, high-fat diet (6 weeks), or high-fat diet with daily SS31 treatment. (C) Muscle GSHt in standard chow–fed, high-fat diet–fed, and high-fat diet–fed plus SS31-treated rats. Data represent mean ± SEM; n = 4–6, *P < 0.05 vs. corresponding fasted state (i.e., before glucose injection); †P < 0.05 vs. Std chow before glucose injection; ‡P < 0.05 vs. all other groups.