Table 3.

The function of five hub proteins shared by RA and T1D and supporting publications.

Protein name	Function(GO)	Association with RA	Association with T1D	Pubmed id
HLA class I histocompatibility antigen	Immune response	Yes	Yes	11369787
Radiation-inducible immediate-early gene IEX-1	NOT found in GO	Yes	Yes	16368886, 14630199
Collagen alpha	Integral to membrane; Beta-amyloid binding; Heparin binding	Yes	No	8816431
Death domain-associated protein 6	Nucleus; Protein binding; Protein homodimerization acitivity; Transcription factor binding	No	No	n/a
Mediator of DNA damage checkpoint protein 1	Nucleus; Protein binding	Yes	No	17913746