Scheme 8.
a) DIBAL-H, 0°C, PhMe, 92%; b) furfurylamine·HCl, NaBH4, MeOH, 3 Å MS, 23°C, 99%; c) KCN, [18]crown-6, [Pd(PPh3)4], PhH, 75°C, 75%; d) Br2, 1:1 AcOH/water, 0°C, 65%; e) [0.15 m] toluene, 170°C, 5 d, 73%.
a) DIBAL-H, 0°C, PhMe, 92%; b) furfurylamine·HCl, NaBH4, MeOH, 3 Å MS, 23°C, 99%; c) KCN, [18]crown-6, [Pd(PPh3)4], PhH, 75°C, 75%; d) Br2, 1:1 AcOH/water, 0°C, 65%; e) [0.15 m] toluene, 170°C, 5 d, 73%.