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. Author manuscript; available in PMC: 2009 Feb 27.
Published in final edited form as: J Comput Aided Mol Des. 2008 Sep 9;23(1):37–47. doi: 10.1007/s10822-008-9236-1

Table 2.

SAR of the fifteen new PDZ domain inhibitors

Sidechain SAR
R1 -ph > -2-furan
-ph > -ph-4-N(CH2CH2Cl)2
-ph-4-Cl > -ph-4-F > ph
-ph-4-Br > -ph-3,5-2(OCH3)
-5-benzo[d][1,2]dioxol > ph-4-OCH3
Exception: ph> ph-4-Cl > ph-4-F (B2)
R2 -2-furan > -ph
-ph-4(OCH3) > -ph