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. Author manuscript; available in PMC: 2009 Nov 19.
Published in final edited form as: J Am Chem Soc. 2008 Oct 29;130(46):15611–15626. doi: 10.1021/ja805649f

Figure 1.

Figure 1

The previously reported15 scheme for the synthesis of a DNA-templated macrocycle library, where R is −NHCH3 or tryptamine, and Ar is −(p-C6H4)–. In contrast with the capping-based method described in the present work, each DNA-templated reaction in this scheme requires a bond formation step, a streptavidin bead capture step, a washing step, and a product elution step.