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. Author manuscript; available in PMC: 2009 Nov 19.
Published in final edited form as: J Am Chem Soc. 2008 Oct 29;130(46):15611–15626. doi: 10.1021/ja805649f

Figure 2.

Figure 2

A capping-based strategy for DNA-templated macrocycle synthesis. The use of a capping reagent (here, acetic anhydride) prevents unreacted or improperly reacted material from participating in further reactions. The final streptavidin bead capture and macrocyclization steps achieve effective purification of the final product, obviating the need to purify after each DNA-templated reaction as in Figure 1 and reducing the total number of required manipulations.