Figure 8.

Eight scaffolds for DNA-templated macrocycle syntheses. The tartaramide group (aldehyde precursor) can be placed on either the α-amine or side-chain (“s”) amine, resulting in two different orientations of building blocks within the resulting macrocycles. The eight scaffolds (denoted by the circled S) were transformed into their corresponding macrocycles using the same reagents used in the synthesis of macrocycle 8b from scaffold 1b; the respective overall percent yields for final purified macrocycles are shown in the table above.