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. Author manuscript; available in PMC: 2009 Feb 27.
Published in final edited form as: Science. 2008 Dec 5;322(5907):1562–1565. doi: 10.1126/science.1164511

Fig. 3.

Fig. 3

Tregs specific for non-inherited maternal alloantigens persist long after birth. (A) CD8+ T cell proliferation in mock-depleted (gray histograms) and CD25-depleted (unshaded histograms) T cells after an 8-day MLR with maternal (left) and paternal (right) APCs. Three children from a single family are represented. (B) Summary of all children tested, comparing the relative increase in proliferation after depletion of CD25+ cells from MLRs against maternal (left) or paternal (right) APCs (1:3 ratio of APCs: responders). Statistical analysis calculated by Mann-Whitney U rank sum test. (C) Summary of individual responses of all children tested, showing proliferation of mock-depleted (PBMC) or CD25-depleted (CD25−) T cells in response to maternal or paternal APCs. Two different dilutions of APCs:responders (1:3, top; 1:30, bottom) are depicted. Statistical significance was determined by paired Student’s t test.