Table 1.
HBV core promoter mutations and HBeAg status and viral loads.
| Groups | No. | Agea | Genotypeb (B/C/O/U) | Triple mutation (T1753V) | Triple mutation (C1766T) | Quadruple mutation (T1753V/C1766T) | Mutation (nt 1809–1817) | Precore stop mutation | Viral loads |
|---|---|---|---|---|---|---|---|---|---|
| Median (range) | |||||||||
| Male | |||||||||
| HBeAg | |||||||||
| 1762/1764: Wild-type | 23 | 34.9 ± 6.0 | 1/14/1/7 | 0 | 0 | 0 | 0 | 1 | 4.3 × 108 (3.0 × 106, 9.0 × 109) |
| 1762/1764: mutant | 25 | 36.4 ± 5.7 | 0/19/0/6 | 8 | 0 | 0 | 1 | 0 | 2.2 × 107 (3.9 × 105, 3.6 × 108) |
| anti-HBe | |||||||||
| 1762/1764: Wild-type | 24 | 40.5 ± 6.2 | 8/11/0/4 | 0 | 0 | 0 | 4 | 13 | 4.6 × 104 (1.9 × 102, 1.9 × 108) |
| 1762/1764: mutant | 26 | 38.2 ± 6.0 | 4/19/0/3 | 13 | 2 | 1 | 4 | 7 | 1.6 × 105 (2.7 × 103, 2.0 × 109) |
| Female | |||||||||
| HBeAg | |||||||||
| 1762/1764: Wild-type | 25 | 34.8 ± 6.0 | 1/18/0/6 | 0 | 0 | 0 | 2 | 1 | 2.6 × 108 (5.5 × 105, 1.6 × 109) |
| 1762/1764: mutant | 18 | 37.8 ± 5.9 | 0/17/0/1 | 5 | 0 | 0 | 1 | 0 | 5.6 × 107 (2.2 × 104, 6.8 × 108) |
| anti-HBe | |||||||||
| 1762/1764: Wild-type | 25 | 43.8 ± 6.9 | 9/12/1/3 | 0 | 0 | 0 | 6 | 20 | 1.5 × 105 (6.9 × 102, 4.2 × 107) |
| 1762/1764: mutant | 24 | 42.1 ± 7.1 | 0/21/1/1 | 15 | 1 | 1 | 4 | 11 | 8.9 × 104 (4.9 × 102, 1.9 × 108) |
a
Ages are means ± standard deviation.
b
B and C: genotypes B and C; O: other genotypes, such genotype A or D; U: undetermined genotype using the current programme.