Table 3.
Longitudinal analysis of HBV double mutations and HBeAg status and viral loads.
| Groups | No. | Viral loads |
|||
|---|---|---|---|---|---|
| Month 0 | Month 12 | Month 24 | Month 36 | ||
| Median (range) | Median (range) | Median (range) | Median (range) | ||
| HBeAg (+) | |||||
| 1762/1764: wild-type | 13 | 2.8 × 108 (3.0 × 106, 9.0 × 109) | 2.0 × 108 (2.0 × 107, 1.5 × 109) | 2.5 × 108 (2.2 × 105, 1.3 × 109) | 2.8 × 108 (6.3 × 106, 1.3 × 109) |
| 1762/1764: mutant | 9 | 1.5 × 107 (2.2 × 104, 4.5 × 108) | 1.7 × 107 (8.0 × 105, 5.2 × 108) | 2.5 × 107 (3.2 × 105, 1.9 × 108) | 3.3 × 107 (2.5 × 105, 3.6 × 108) |
| p-valuea | 0.02 | 0.001 | 0.04 | 0.008 | |
| anti-HBe (+) | |||||
| 1762/1764: wild-type | 17 | 8.5 × 104 (2.8 × 102, 1.5 × 108) | 7.7 × 104 (6.4 × 102, 5.0 × 107) | 1.2 × 104 (7.8 × 101, 8.5 × 105) | 1.8 × 104 (1.3 × 102, 6.8 × 105) |
| 1762/1764: mutant | 19 | 8.1 × 104 (4.9 × 102, 2.0 × 109) | 3.7 × 104 (3.8 × 102, 4.4 × 106) | 1.4 × 104 (5.2 × 101, 1.4 × 106) | 4.6 × 104 (1.2 × 102, 2.0 × 108) |
| p-valuea | 0.61 | 0.25 | 0.61 | 0.12 | |
a
p-Value obtained from unpaired t-test after log transformation.