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. 2009 Mar 6;4(3):e4728. doi: 10.1371/journal.pone.0004728

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Almendro et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A) Non-resistant (HT29, HCT116 p53^+/+, HCT116 p53^−/−) and resistant cells (RHT29, RHCT116 p53^+/+, RHCT116 p53^−/−) were assessed by MTS for its response to oxaliplatin treatment. The dose-response curve shows a higher IC50 for the resistant cell lines than for the parental cells as expected. Results are represented as mean±SEM for 6 samples in each group. B) HT29 and RHT29 cell lines were treated or not with oxaliplatin at 10 µM for 48 hours and apoptosis induction was detected by Annexin V/IP staining. These are representative graphics of 3 samples per group, showing less apoptotic induction in the RHT29 cell line. OXA: oxaliplatin.