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. 2008 Dec 8;10(2):352–363. doi: 10.1093/biostatistics/kxn042

Table 3.

Bias and standard deviation (shown in brackets) in estimating α for the 4 estimation methods in 9 different scenarios. The true values of α and σ in each scenario are shown in the first 2 columns, and μ = 100 for all scenarios. All values are given to 2 significant figures

σ α MLE Saddle RMA-75 RMA
5 102 – 0.00013 (0.75) 0.25 (0.75) – 1.1 (1.5) – 80 (0.31)
20 102 – 0.013 (0.82) – 0.023 (0.84) – 2.5 (1.9) – 79 (0.40)
100 102 – 0.046 (1.6) – 11.0 (1.5) 27.0 (8.1) – 69 (4.4)
5 103 0.021 (6.8) 0.37 (6.8) – 2.8 (10) – 800 (2.9)
20 103 0.11 (6.8) 1.4 (6.8) – 4.6 (12) – 800 (2.9)
100 103 – 0.16 (7.5) 3.2 (7.5) – 15.0 (16) – 790 (3.2)
5 104 0.50 (72) 1.0 (72) – 28.0 (100) – 8000 (28)
20 104 – 3.2 (69) – 1.6 (69) – 29.0 (100) – 8000 (28)
100 104 3.1 (71) 9.5 (71) – 23.0 (110) – 8000 (30)