TABLE 3.
FAMILY-BASED ANALYSIS OF ASSOCIATION BETWEEN VARIANTS IN TGFB1 AND AIRWAY RESPONSIVENESS AND ASTHMA EXACERBATIONS IN CAMP AND COSTA RICA*
| Costa-Rica
|
CAMP
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Phenotype | dbSNP | Allele | Allele Frequency | Informative Families, n | Z Score | P Value | Allele | Allele Frequency | Informative Families, n | Z Score | P Value | Fisher's Combined P Value† |
| Airway responsiveness | rs1800469 | C | 0.57 | 138 | −2.87 | 0.004 | C | 0.70 | 110 | −2.24 | 0.01 | 0.0004 |
| rs2241712 | A | 0.56 | 128 | −3.43 | 0.0006 | A | 0.70 | 108 | −2.58 | 0.005 | 0.00004 | |
| Asthma hospitalizations‡ | rs1982073 | T | 0.55 | 165 | −2.58 | 0.009 | T | 0.59 | 219 | −2.41 | 0.005 | 0.0005 |
*
All analyses were conducted under the assumption of a dominant genetic model.
†
Combined P value ≤ 0.001, which is significant after correction for multiple comparisons.
‡
In Costa Rica, at least one hospitalization for asthma in the previous year. In CAMP, at least one hospitalization or emergency department visit for asthma in the year preceding randomization.