Table 4.
Risk of new onset of specific comorbidity in the cohort with non-specific chest pain compared with controls.
| Cohort with chest pain | Controls | ||||
|---|---|---|---|---|---|
| na | New cases | na | New cases | Risk ratiob of a new diagnosis (95% CI) | |
| Gastrointestinal | |||||
| GORD | 2612 | 80 | 8287 | 55 | 4.5 (3.1 to 6.4) |
| Dyspepsia | 2297 | 103 | 7681 | 79 | 4.1 (3.0 to 5.6) |
| Peptic ulcer disease | 2910 | 7 | 8786 | 7 | 2.7 (0.9 to 8.1) |
| IBS | 2775 | 17 | 8540 | 22 | 1.8 (0.9 to 3.4) |
| Psychological | |||||
| Anxiety | 2469 | 66 | 7910 | 86 | 2.0 (1.4 to 2.8) |
| Depression | 2300 | 75 | 7585 | 115 | 1.7 (1.2 to 2.3) |
| Stress | 2739 | 46 | 8477 | 58 | 2.0 (1.4 to 3.0) |
| Sleep disorders | 2614 | 40 | 8265 | 64 | 1.5 (1.0 to 2.3) |
| Respiratory | |||||
| Asthma | 2641 | 27 | 8182 | 17 | 3.9 (2.1 to 7.4) |
| COPD | 2922 | 9 | 8833 | 25 | 0.9 (0.4 to 2.0) |
| Pneumonia | 2961 | 14 | 8834 | 9 | 3.6 (1.5 to 8.7) |
| Musculoskeletal | 1115 | 170 | 4538 | 353 | 1.9 (1.6 to 2.3) |
a
Number of patients without the specific diagnosis in the 12 months before chest pain consultation.
b
Risk ratio of the risk of first-time diagnosis of specific outcomes in the group with non-specific chest pain compared to controls. Estimates are adjusted forage, sex, visits to the GP in the previous year, BMI, alcohol use, smoking, and chest pain diagnosis, using logistic regression. COPD = chronic obstructive pulmonary disease; GORD = gastroesophageal reflux disease; IBS = irritable bowel syndrome.