Table 1.

Randomized studies of WBRT and radiosensitizers versus WBRT alone

Study	Study arms	No. of pts randomized	Overall median survival	Overall survival at 6 months	Response (CR + PR)
DeAngelis (19)	3000 cGy/10 fr + lonidamine	31	4.0 m	NR	37%
	3000 cGy/10 fr	27	5.4 m		55%
Eyre (20)	3000 cGy/10 fr + metronidazole	57	2.8 m	14	27%
	3000 cGy/10 fr	54	3.2 m	13	24%
RTOG-7916(21)	3000 cGy/6 fr + misonidazole	220	3.1 m	68	NR
	3000 cGy/6 fr	216	4.1 m	83
	3000 cGy/10 fr + misonidazole	211	3.9 m	65
	3000 cGy/10 fr	212	4.5 m	72
Mehta(23)	3000 cGy/10 fr + MGd	193	5.2 m	82	NR
	3000 cGy/10 fr	208	4.9 m	85
RTOG-8905(22)	3750 cGy/15 fr + BrdUrd	35	4.3 m	12	63%
	3750 cGy/15 fr	37	6.12 m	20	50%
REACH (25)	3000 cGy/10 fr + RSR13	265	5.4 m	119	48%
	3000 cGy/10 fr	250	4.4 m	96	36%
RTOG- 0118(26)	3750cGy/15 fr + thalidomide	90			NR
	3750 cGy/15 fr	93
SMART(24)	3000 cGy/10 fr + MGd	279	NR	NR	NR
	3000 cGy/10 fr	275