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. 2008 Jul;22(7):1501–1503. doi: 10.1089/end.2007.0314

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Copyright 2008, Mary Ann Liebert, Inc.

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FIG. 3. — Adrenal and extra-adrenal pheochromocytoma. (A) Representative section of adrenal tumor showing small nests of polygonal cells with amphophilic cytoplasm and round nuclei. Immunohistochemical studies performed showed positivity for chromogranin and synaptophysin, while sustentacular cells are highlighted by S-100 (data not shown) (hematoxylin and eosin, original magnification 10×). (B) Gross and histologic appearance of the extra-adrenal mass. (C) The tumor (asterisk) is surrounded by ganglion and peripheral nerve tissue (hematoxylin and eosin, original magnification 2×). The histologic features are consistent with an extra-adrenal pheochromocytoma. (D) Higher magnification view of ganglion cells (arrow) juxtaposed to the pheochromocytoma (asterisk) (hematoxylin and eosin, original magnification 10×).