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Peptide GRR interacting at two binding sites of WNV NS2B-NS3 protease. SwissPDB was used to mutate residues of aprotinin (PDB reference code 2IJO) from PCK to GRR in the P3-P1 positions (green), and from ARL to GRR in the P1′-P3′ positions (blue). Substrate positions for binding to polyprotein are designated according to standard nomenclature. The protease is colored grey, and active site is colored magenta. PYMOL (41) was used to generate the figure.
