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. Author manuscript; available in PMC: 2009 Nov 11.
Published in final edited form as: Biochemistry. 2008 Oct 15;47(45):11763–11770. doi: 10.1021/bi801034f

Table 1.

Kinetic Parameters for the WNV NS2B-NS3 Protease a

Substrate Kd (μM) Kd2 (μM) kcat (s−1) kcat/Kd (M−1 s−1)
Boc-GRR-AMC 117 ± 19 1366 ± 386 0.026 ± 0.002 222 ± 35
Ac-DFASGKR-AMC 800 ± 210 1204 ± 483 0.196 ± 0.067 245 ± 84
a

GRR experiments were repeated three times in triplicate. DFASGKR experiments were repeated twice in triplicate.