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c-MYC siRNA-mediates reduced susceptibility to cisplatin (A) and etoposide (B) treatment. Cytotoxicity induced by etoposide and cisplatin in c-MYC siRNA and in control siRNA-transfected cells was determined by the MTS assay. Values represent the mean percentage of survival compared to control cells (n = 3; ± SD). The IC50 values and their 95% confidence intervals were calculated from the regression curve and are indicated for each data set.
