Table 2.
Association between c-erbB-2 expression and clinicopathological data in 185 cases of ESCC analyzed by TMA
| Variables | Category | c-erbB-2 | |||
|---|---|---|---|---|---|
| Negative [0 and 1+] (%) |
Positive [2 and 3+] (%) |
Total | p value | ||
| Gender | Male | 97 (82.9) | 52 (76.5) | 149 | 0.337 |
| Female | 20 (17.1) | 16 (23.5) | 36 | ||
| Age | < 60 years | 61 (54.5) | 46 (69.7) | 107 | 0.057 |
| ≥ 60 years | 51 (45.5) | 20 (30.3) | 71 | ||
| Ethnicity | Caucasian | 84 (77.1) | 52 (77.6) | 136 | 1.000 |
| No Caucasian | 25 (22.9) | 15 (22.4) | 40 | ||
| Tumor location | Upper | 18 (16.2) | 12 (18.8) | 30 | 0.781 |
| Middle | 65 (58.6) | 34 (53.1) | 99 | ||
| Lower | 28 (25.2) | 18 (28.1) | 46 | ||
| Histological grade | G1+G2 | 87 (74.4) | 57 (83.8) | 144 | 0.147 |
| G3+G4 | 30 (25.6) | 11 (16.2) | 41 | ||
| Infiltration level | Basal layer | 5 (4.3) | 0 (0) | 5 | NA |
| Muscular | 22 (18.8) | 17 (25) | 39 | ||
| Adventitia | 90 (76.9) | 51 (75) | 141 | ||
| Lymphatic invasion | Not observed | 30 (25.6) | 19 (27.9) | 49 | 0.733 |
| Present | 87 (74.4) | 49 (72.1) | 136 | ||
| Venous invasion | Not observed | 95 (81.2) | 54 (79.4) | 149 | 0.848 |
| Present | 22 (18.8) | 14 (20.6) | 36 | ||
| pN | Negative | 63 (53.8) | 36 (52.9) | 99 | 1.000 |
| Positive | 54 (46.2) | 32 (47.1) | 86 | ||
| Surgical margins | Not committed | 110 (95.7) | 67 (98.5) | 177 | NA |
| Committed | 5 (4.3) | 1 (1.5) | 6 | ||
| Stage | 1+2 | 58 (49.6) | 27 (39.7) | 85 | 0.222 |
| 3+4 | 59 (50.4) | 41 (60.3) | 100 | ||
| Recurrence | Negative | 49 (42.6) | 28 (41.8) | 77 | 1.000 |
| Positive | 66 (57.4) | 39 (58.2) | 105 | ||
NA: not available