. Author manuscript; available in PMC: 2009 Dec 25.

Published in final edited form as: J Med Chem. 2008 Dec 25;51(24):8027–8037. doi: 10.1021/jm800649q

Table 1. Inhibition of PLA₂ by fluoroketones.

Average percent inhibition and standard error (n=3) reported for each compound at 0.091 mole fraction. X_I(50) values determined for inhibitors with greater than 90% inhibition. N.D. signifies compounds with less than 25% inhibition (or no detectable inhibition).

No	Structure	GIVA cPLA₂		GVIA iPLA₂		GV sPLA₂
No	Structure	% Inhibition	X_I(50)	% Inhibition	X_I(50)	% Inhibition	X_I(50)
6		96 ± 2	0.0223 ± 0.0023	92 ± 3	0.0195 ± 0.0053	79 ± 9
11		N.D.		50 ± 13		43 ± 8
8		38 ± 2		96 ± 3	0.0096 ±0.0008	N.D.
10a		N.D.		98 ± 16	0.0073 ± 0.0007	28 ± 1
12a		62 ± 5		96 ± 6	0.0025 ± 0.0003	48 ± 6
10b		56 ± 4		98 ± 5	0.0065 ± 0.001	46 ± 8
12b		68 ± 6		99 ± 10	0.0018 ± 0.0005	53 ± 14
10c		65 ± 12		98 ± 4	0.0065 ± 0.0008	75 ± 10
19a		91 ± 2	0.0199 ± 0.0025	85 ± 4	0.0328 ±0.0035	82 ± 8
20a		92 ± 3	0.0098 ± 0.0006	91 ± 4	0.0169 ±0.0021	86 ± 2
19b		96 ± 2	0.0156 ± 0.0019	94 ± 8	0.0208 ±0.0032	80 ± 6
20b		95 ± 2	0.0116 ± 94 ± 8	94 ± 8	0.0166 ±0.0022	84 ± 7
23		88 ± 1		71 ± 14		49 ± 12
21		73 ± 4		95 ± 5	0.0075 ±0.0011	86 ± 4
30		27 ± 3		49 ± 12		59 ± 12
26		94 ± 2	0.0167 ± 0.0018	93 ± 4	0.0011 ± 0.0002	86 ± 10	0.0236 ± 0.004

Table 1. Inhibition of PLA2 by fluoroketones.

Table 1. Inhibition of PLA₂ by fluoroketones.