Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Summary of common variants identified in MC4R and MC3R
| Gene | Variant | No. severely obese carriers (n = 889) | No. lean control carriers (n = 932) | P-value |
|---|---|---|---|---|
| MC4R | Val103Ile | 19 | 22 | 0.755 |
| Leu251Ile | 6 | 6 | 0.774 | |
| MC3R | Arg257Ser | 1 | 7 | 0.070 |
| Thr6Lys/Val81Ile Haplotype | ||||
| Wild-type | 391 | 414 | 0.950 | |
| Heterozygous for 6K/81I | 93 | 113 | ||
| Homozygous for 6K/81I | 13 | 11 | ||
The number of severely obese adult carriers (out of n = 889) and lean control carriers (out of n = 932) for each variant for both MC4R and MC3R are listed.
