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Age-dependent reductions in circulating leptin and adiponectin levels in R6/2 Tg and CAG140 KI mice. (A) Leptin and (B) adiponectin levels were determined in fasting plasma samples from female R6/2 Tg and CAG140 KI mice and wt littermates at the ages indicated (n = 4–5 mice for each genotype). Values represent mean ± SD. *P < 0.05 versus the corresponding wt group.
