Table 1.
Results of allelic association for QC-checked SNPs in EAs, HAs, Korean and Japanese populations
Gene | SNP | Allele† | European-American |
Hispanic-American |
Korean |
Japanese |
||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MAF |
MAF |
MAF |
MAF |
|||||||||||||||
Case | Control | P-value | OR (95% CI) | Case | Control | P-value | OR (95% CI) | Case | Control | P-value | OR (95% CI) | Case | Control | P-value | OR (95% CI) | |||
TRIM72 | rs8056505 | GA | 0.3 | 0.32 | 0.16 | 0.9 (0.78–1.04) | 0.42 | 0.39 | 0.33 | 1.11 (0.89–1.37) | 0.17 | 0.19 | 0.19 | 0.88 (0.73–1.06) | 0.16 | 0.17 | 0.93 | 0.47 (0.11,1.48) |
ITGAM | rs8057320 | GA | 0.29 | 0.31 | 0.14 | 0.89 (0.77–1.03) | 0.39 | 0.37 | 0.64 | 1.05 (0.84–1.3) | 0.18 | 0.20 | 0.14 | 0.87 (0.72–1.04) | 0.17 | 0.18 | 0.68 | 0.93 (0.66–1.29) |
ITGAM | rs7193943 | GA | 0.28 | 0.30 | 0.16 | 0.9 (0.77–1.04) | 0.36 | 0.30 | 0.37 | 1.1 (0.88–1.37) | 0.18 | 0.20 | 0.14 | 0.87 (0.72–1.04) | 0.16 | 0.18 | 0.61 | 0.918 (0.65–1.27) |
ITGAM | rs11865830 | GA | 0.28 | 0.31 | 0.17 | 0.9 (0.78–1.04) | 0.37 | 0.36 | 0.77 | 1.03 (0.83–1.28) | 0.18 | 0.20 | 0.13 | 0.86 (0.72–1.04) | 0.17 | 0.18 | 0.52 | 1.07 (0.72–1.61) |
ITGAM | rs1143679 | AG | 0.18 | 0.11 | 1.04 × 10−8 | 1.73 (1.43–2.10) | 0.16 | 0.09 | 2.85 × 10−5 | 2.09 (1.47–2.98) | 0 | 0 | – | – | 0 | 0 | – | – |
ITGAM | rs8048583 | AG | 0.3 | 0.32 | 0.16 | 0.9 (0.78–1.04) | 0.41 | 0.41 | 0.86 | 1.01 (0.82–1.26) | 0.19 | 0.22 | 0.06 | 0.84 (0.7–1.01) | 0.17 | 0.19 | 0.54 | 1.11 (0.79–1.54) |
ITGAM | rs9936831 | TA | 0.18 | 0.12 | 1.41 × 10−7 | 1.63 (1.35–1.96) | 0.19 | 0.11 | 0.0001 | 1.81 (1.32–2.47) | 0 | 0 | – | – | – | – | – | – |
ITGAM | rs11861251 | GA | 0.13 | 0.14 | 0.52 | 0.93 (0.77–1.13) | 0.07 | 0.07 | 0.82 | 0.95 (0.63–1.42) | 0 | 0 | – | – | – | – | – | – |
ITGAM | rs9888879 | GA | 0.19 | 0.12 | 6.92 × 10−8 | 1.64 (1.36–1.96) | 0.21 | 0.15 | 0.001 | 1.57 (1.18–2.09) | 0 | 0 | – | – | – | – | – | – |
ITGAM | rs12928810 | AG | 0.19 | 0.12 | 6.92 × 10−8 | 1.64 (1.36–1.96) | 0.15 | 0.11 | 0.02 | 1.44 (1.04–1.99) | 0 | 0 | – | – | – | – | – | – |
ITGAM | rs9888739 | AG | 0.19 | 0.12 | 3.90 × 10−8 | 1.65 (1.38–1.98) | 0.21 | 0.15 | 0.001 | 1.58 (1.18–2.1) | 0 | 0 | – | – | – | – | – | – |
ITGAM | rs7499077 | AG | 0.33 | 0.27 | 8.56 × 10−5 | 1.33 (1.15–1.54) | 0.29 | 0.22 | 0.008 | 1.39 (1.08–1.77) | 0 | 0 | – | – | – | – | – | – |
ITGAM | rs11860650 | AG | 0.18 | 0.12 | 1.34 × 10−7 | 1.64 (1.36–1.97) | 0.17 | 0.10 | 0.0001 | 1.91 (1.37–2.67) | 0 | 0 | – | – | – | – | – | – |
ITGAM | rs6565227 | TA | 0.19 | 0.12 | 8.76 × 10−8 | 1.63 (1.36–1.95) | 0.21 | 0.15 | 0.001 | 1.57 (1.18–2.09) | 0 | 0 | – | – | – | – | – | – |
ITGAM | rs7206295 | AG | 0.29 | 0.31 | 0.11 | 0.88 (0.76–1.02) | 0.40 | 0.39 | 0.72 | 1.04 (0.83–1.28) | 0.19 | 0.22 | 0.042 | 0.82 (0.69–0.99) | 0.16 | 0.18 | 0.51 | 1.11 (0.79–1.56) |
ITGAM | rs1143683 | AG | 0.22 | 0.15 | 7.98 × 10−7 | 1.52 (1.29–1.81) | 0.19 | 0.12 | 0.0001 | 1.79 (1.31–2.43) | 0 | 0 | – | – | – | – | – | – |
ITGAM | rs1143678 | AG | 0.22 | 0.15 | 7.98 × 10−7 | 1.52 (1.29–1.81) | 0.20 | 0.12 | 0.0004 | 1.71 (1.26–2.31) | 0 | 0 | – | – | – | – | – | – |
ITGAM | rs4597342 | AG | 0.29 | 0.31 | 0.15 | 0.9 (0.78–1.04) | 0.40 | 0.39 | 0.85 | 1.02 (0.82–1.26) | 0.19 | 0.23 | 0.045 | 0.83 (0.69–0.99) | 0.17 | 0.18 | 0.65 | 1.08 (0.77–1.5) |
Outer | rs4506917 | CA | 0.47 | 0.51 | 0.01 | 0.83 (0.73–0.95) | 0.35 | 0.42 | 0.01 | 0.75 (0.61–0.93) | 0.21 | 0.24 | 0.09 | 0.86 (0.72–1.02) | – | – | – | – |
Outer | rs4075052 | AC | 0.29 | 0.31 | 0.14 | 0.89 (0.77–1.03) | 0.40 | 0.40 | 0.92 | 1.01 (0.81–1.25) | 0.21 | 0.24 | 0.07 | 0.85 (0.71–1.01) | – | – | – | – |
Outer | rs4261553 | AG | 0.29 | 0.31 | 0.16 | 0.90 (0.78–1.04) | 0.40 | 0.40 | 0.94 | 1 (0.81–1.24) | 0.21 | 0.24 | 0.07 | 0.85 (0.71–1.01) | 0.18 | 0.26 | 0.68 | 0.68 (0.22–1.82) |
Outer | rs11150613 | GA | 0.30 | 0.32 | 0.21 | 0.91 (0.79–1.05) | 0.40 | 0.40 | 0.96 | 1 (0.81–1.24) | 0.21 | 0.24 | 0.09 | 0.85 (0.72–1.02) | – | – | – | – |
ITGAX | rs2230429 | CG | 0.31 | 0.34 | 0.05 | 0.87 (0.75–1) | 0.28 | 0.35 | 0.004 | 0.72 (0.57–0.9) | 0.21* | 0.22 | 0.24 | 0.90 (0.75–1.08) | 0.16 | 0.18 | 0.23 | 0.35 (0.07–1.25) |
ITGAX | rs9929832 | GA | 0.50 | 0.47 | 0.09 | 1.12 (0.98–1.28) | 0.48* | 0.49 | 0.61 | 0.94 (0.76–1.17) | 0.23 | 0.22 | 0.37 | 1.08 (0.91–1.29) | 0.16 | 0.17 | 0.96 | 1.05 (0.72–1.61) |
MAF, minor allele frequency.
*Minor allele flipped.
†Minor allele/major allele.