Table 1.

Protein evolutionary rates distribution along the signaling information flow

Cellular location	Extracellular	Membrane	Cytoplasm	Nucleus
dN/dS (median)	0.220	0.108	0.086	0.094
P value*	1.36 × 10-5	0.01	0.04	0.13

*The P values were calculated by Wilcoxon test by comparing the protein evolutionary rates in each group with the evolutionary rates of the whole network proteins.