FIGURE 1.

Profiles of histone H3 modifications at the mouse Retn locus on chromosome 8. ChIP-chip mapping of H3K4me3, H3K4me2 and H3K9ac was performed in undifferentiated (preadipocyte) and differentiated (adipocyte) 3T3-L1 cells. Fold-enrichment values are plotted on a linear scale along a region of mouse chromosome 8 containing Retn and neighboring genes. Gaps indicate the presence of repetitive sequence. Retn and Stxbp2 transcription proceeds from left to right, while Pcp2 and Xab2 proceeds from right to left. The arrow indicates the enrichment peak for H3K4me2 and H3K9ac that is positioned 9-kb upstream of Retn.