TABLE 3.

Structure-based sequence alignment

N-terminal calcium binding loop of CaM aligned with the respective N-terminal EF-hand loop sequences from Na_v1.2 and Na_v1.5 CTD sequences, based on a structural alignment between apo-CaM and the Na_v1.2 CTD.

Ca2+ coordination	X		Y		Z		−Y		−X			−Z
Position	1	2	3	4	5	6	7	8	9	10	11	12
Nav1.2	D	P	D	A	T	Q	F	I	E	F	A	K
Nav1.5	D	P	E	A	T	Q	F	I	E	Y	S	V
CaM	D	K	D	G	D	G	T	I	T	T	K	E