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. 2009 Mar 6;284(10):6249–6259. doi: 10.1074/jbc.M807997200

FIGURE 2.

FIGURE 2.

Circulating corticosterone and ACTH levels are reduced in GRM610L mice. A and B, daytime (A) and nighttime (B) plasma corticosterone levels in GRM610L mice and WT littermates. C and D, daytime (C) and nighttime (D) plasma ACTH levels in GRM610L mice and WT littermates. GRM610L heterozygous and homozygous mice have a highly significant decrease in plasma corticosterone and ACTH levels compared with wild-type animals. E and F, corticosterone (E) and ACTH (F) levels in control and GRM610L littermates after 30-min restraint stress. G, corticosterone levels in control and GRM610L littermates after 36 h fasting. H, corticosterone levels in control and GRM610L mice littermates 20 min after ACTH injection (10 μg/kg, intraperitoneal). I, aldosterone levels in control and GRM610L mice littermates. *, p < 0.05; **, p < 0.01.