TABLE 1.
Expression of PDGFRα promoted non-PDGF-driven cell proliferation and survival The indicated cellular responses were assayed as described in the legend of Figs. 5 and 6. The mean ± S.D. of the bFGF-induced-fold change from three independent experiments is shown.
|
Cells
|
Without NAC treatment
|
With NAC treatment
|
||||
|---|---|---|---|---|---|---|
| - | bFGF | PDGF-A | - | bFGF | PDGF-A | |
| fold | fold | |||||
| Proliferation | ||||||
| F | 1.0 | 1.46 ± 0.02 | NA | 1.0 | 1.75 ± 0.03 | NA |
| FαΔx | 1.0 | 1.95 ± 0.06a | NA | 1.0 | 1.75 ± 0.03 | NA |
| Fα | 1.0 | 1.98 ± 0.03a | 2.20 ± 0.03 | 1.0 | 1.75 ± 0.02 | 2.13 ± 0.08 |
| Apoptosis | ||||||
| F | 1.0 | 0.68 ± 0.04 | NA | 1.0 | 0.73 ± 0.04 | NA |
| FαΔx | 1.0 | 0.18 ± 0.04a | NA | 1.0 | 0.72 ± 0.02 | NA |
| Fα | 1.0 | 0.17 ± 0.03a | 0.15 ± 0.02 | 1.0 | 0.70 ± 0.02 | 0.63 ± 0.04 |
a
Statistically significant difference (p < 0.05) between F and Fα or FαΔX