Table 2.
Genes differentially expressed between oral tongue tumor and case-matched histologically normal mucosae (TN paired, n = 20)
| Accession | Sequence identity (GenBank/EMBL) | Average log fold change |
|---|---|---|
| Nuclear proteins (transcription factors, DNA processing enzymes) | ||
| AJ001381 | Mutated allele of a myosin class I, myh-1c | 5.24 |
| D28364 | Annexin II | 4.61 |
| M92383 | Thymosin beta-10 | 3.75 |
| U22431 | Hypoxia-inducible factor 1 alpha (HIF-1 alpha) | 3.47 |
| M86400 | Phospholipase A2 | 3.27 |
| L19779 | Histone H2A.2 | 2.99 |
| U10860 | Guanosine 5-monophosphate synthase | 2.71 |
| U12472, U21689 | Glutathione S-transferase (GST phi) | 2.70 |
| J04173 | Phosphoglycerate mutase (PGAM-B) | 2.69 |
| AL009179 | Histone H2B | 2.58 |
| D13748 | Eukaryotic initiation factor 4AI | 2.57 |
| S79639 | Exostosin 1 (EXT1) | 2.39 |
| AL049650 | snRNP (small nuclear ribonucleoprotein particle) protein B) | 2.35 |
| Ras-Like Protein Tc4 | 2.27 | |
| D26599 | Proteasome subunit HsC7-I | 2.04 |
| X82554 | SPHAR gene for cyclin-related protein | -1.89 |
| U40490 | Human nicotinamide nucleotide transhydrogenase | -3.53 |
| D83407 | ZAKI-4 in human skin fibroblast | -5.31 |
| Cytokines, growth factors and receptors | ||
| NM001953, M63193 | Platelet-derived endothelial cell growth factor (ECGF1) | 15.89 |
| M77349 | Transforming growth factor-beta induced gene product (BIGH3) | 6.17 |
| U73377 | p66shc (SHC) | 2.37 |
| M35252 | Tumor associated antigen CO-029 | -9.42 |
| Signaling molecules | ||
| AF054183 | GTP binding protein | 2.00 |
| U78525 | Eukaryotic translation initiation factor (eIF3) | 1.89 |
| Metabolic enzymes, transporters, ion channels | ||
| AF042498 | Rod photoreceptor CNG-channel beta subunit (RCNC2) | 6.73 |
| M94856 | Fatty acid binding protein homologue (PA-FABP) | 5.24 |
| M91670 | Ubiquitin carrier protein (E2-EPF) | 3.52 |
| J03626 | UMP synthase | 2.54 |
| D50840 | Ceramide glucosyltransferase | 2.54 |
| U89606 | Pyridoxal kinase | 2.41 |
| Accession | Sequence identity (GenBank/EMBL) | Average log fold change |
| X52851 | Cyclophilin | 2.22 |
| X97074 | Clathrin-associated protein | 2.07 |
| S81003 | L-UBC = ubiquitin conjugating enzyme | 2.04 |
| U09510 | Glycyl-tRNA synthetase | 1.96 |
| D25547 | PIMT isozyme I | 1.87 |
| AF052941 | DAP-kinase related protein 1 | -2.12 |
| D16294 | Mitochondrial 3-oxoacyl-CoA thiolase | -3.59 |
| Extracellular proteins | ||
| M13509 | Skin collagenase (MMP1) | 34.18 |
| X07820 | Stromelysin-2 (MMP7) | 15.89 |
| L10343 | Elafin | 9.95 |
| L23808 | Macrophage metalloelastase (MME, MMP12) | 7.67 |
| U29091 | Human selenium-binding protein (hSBP) | -5.41 |
| Others | ||
| AB018342 | KIAA0799 | 4.44 |
| D21261 | KIAA0120 | 2.59 |
| AB014515 | KIAA0615 | 2.42 |
| AB007889 | KIAA0429 | 2.09 |
| AA586894 | EST | 14.57 |
| AA010777 | EST | 14.12 |
| L05424 | EST | 5.76 |
| AI885852 | EST | 4.03 |
| Z98946 | EST | 3.42 |
| AC002073 | EST | 3.17 |
| AF053356 | EST | 1.73 |
| AB028994 | KIAA1071 | -6.08 |
| D42047 | KIAA0089 | -4.68 |
| AB007972 | KIAA0503 | -3.96 |
| AF007153 | EST | -5.35 |
| AI674208 | EST | -3.57 |
| AL080059 | EST | -3.12 |
| AL049381 | EST | -2.93 |
| AW021542 | EST | -2.60 |