TABLE 1.

Major contraindications for each class of medication

Medication class	Contraindication
Antithrombotic therapy*	Hypersensitivity, bleeding ulcer, thrombocytopenia, hemophilia or a bleeding disorder, hemorrhagic state, alcohol use or abuse
Statins	Hypersensitivity, active liver disease, unexplained or persistent elevation of serum transaminases, marked elevation of creatine phosphokinase, myopathy, rhabdomyolysis
ACEIs	Hypersensitivity, angioedema, renal insufficiency, renal artery stenosis
Beta-blockers	Hypersensitivity, second- or third-degree heart block, overt cardiac failure, moderate or severe congestive heart failure, severe sinus bradycardia, cardiogenic shock, a systolic blood pressure of less than 100 mmHg, myocardial infarction in patient with heart rate of less than 45 beats/min, bronchial asthma or chronic obstructive pulmonary disease, sick sinus syndrome

^*Antithrombotic therapy includes antiplatelet and/or anticoagulant therapy. ACEI Angiotensin-converting enzyme inihibitor