Table 1.

Hepatocyte donor characteristics.

	Donor
Characteristic	1	2	3
State of shipped hepatocyes	Cryopreserved	Fresh	Cryopreserved
Lot no.	KQG	MHU-L-092507	ONQ
Experimental repetitions (n )	2	1	1
Sex	Female	Male	Male
Age (years)	38	50	61
Race	Caucasian	Caucasian	Caucasian
Body mass index	38.6	34.4	42.9
History of alcohol use	Yes	Yes	Yes
History of narcotic use	None reported	None reported	None reported
History of tobacco use	Yes	None reported	Yes
Relevant medical history	None reported	None reported	None reported
Relevant chronic medications	None reported	None reported	None reported
Cause of death	Cerebrovascular accident (stroke)	Head trauma	Head trauma
Initial viability (%)	83.8	93a	83.7
Viable cell density (cells/mL)	7.0 × 105	NA	7.0 × 105
Confluence at 24 hr (%)	80	70	50–60
Metabolic activityb (pmol/106 cells/min)
Formation of 7-hydroxycoumarin	49	N/A	66
Formation of 7-hydroxycoumarin glucuronide	191	NA	247
Formation of 7-hydroxycoumarin sulfate	12	NA	47
Formation of 6β-hydroxytestosterone	108	NA	60
Formation of 4′-methylhydroxytolbutamide	25	NA	18

NA, not available.

^aAt time of plating (measured by supplier).

^bProvided by hepatocyte supplier.