Table 3.

Functional characterization of β₂97 mutant GABA_A receptors

Mutant	LogEC50 ± SEM	EC50 (μm)	EC50mut/EC50phe	nH	n
α1β2	−5.457 ± 0.04	3.5		1.2	4
α1β297-Phe	−6.190 ± 0.16a	0.6	1	1.4	4
α1β297-4-F-Phe	−4.706 ± 0.07a	20	33	1.2	5
α1β297-3,5-F2-Phe	−3.372 ± 0.05a	420	700	1.1	4
α1β297-3,4,5-F3-Phe	−2.002 ± 0.04a	9900	16,500	1.9	5

^aDenotes logEC₅₀ values statistically significantly different from wild type by one-way ANOVA; p < 0.01.