Figure 4.

Homology model of the extracellular domain of the GlyR based on the crystal structure of AChBP with carbamylcholine bound (PDB ID; 1uv6). For ease of viewing, only two of the five subunits have been shown. The ligand binding site is located between the two subunits; glycine (green), F159 (blue), and R65 (red) are colored for clarity. Inset, Enlargement of residues examined in this study showing that docking of glycine is consistent with a cation-π interaction with Phe159, and also with previous studies on Arg 65, which is proposed to make contact with the carboxylate of glycine (Grudzinska et al., 2005). The two images are in different orientations for clarity.