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Inhibition constants derived from [3H] granisetron binding to 5-HT3A and 5-HT3AB receptors
| A (Ki, μM) | AB (Ki, μM) | |
|---|---|---|
| 5-HT | 0.11 ± 0.02 | 0.11 ± 0.03 |
| mCPBG | 0.010 ± 0.003 | 0.012 ± 0.004 |
| 5-FT | 0.83 ± 0.17 | 1.8 ± 0.4 |
| Tryptamine | 4.8 ± 0.9 | 15.5 ± 3.5 |
| 5-Cl-tryptamine | 2.7 ± 0.7 | 3.1 ± 1.1 |
| 5-Me-tryptamine | 11. 0 ± 0.9 | 7.7 ± 1.1 |
| 5-MeO-tryptamine | 34.9 ± 3.0 | 21.7 ± 2.1 |
Data = mean ± SEM, n = 3–6.
