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Inhibition constants derived from [3H] granisetron binding to mutant 5-HT3A receptors
| 5-HT (Ki, μM) | 5-FT (Ki, μM) | |
|---|---|---|
| WT | 0.11 ± 0.02 | 0.83 ± 0.17 |
| N128A | 0.21 ± 0.05 | 2.43 ± 0.47 |
| T181A | 0.19 ± 0.04 | 0.02 ± 0.34 |
| E236A | 0.20 ± 0.05 | 1.62 ± 0.41 |
Data = mean + SEM, n = 3–6.
