Figure 7.

The effect of combined FcγRI and C3 deficiency in IgG2a and IgG2b induced disease. FcγRI-/-→C3-/- bone marrow chimeras were constructed and compared to WT→WT sham chimera controls. A. Numbers of neutrophils infiltrating glomeruli 2 hours after IgG2a anti-TNP monoclonal with endotoxin, given 24 hours after an intravenous injection of TNP conjugated nephrotoxic antibody. The WT→WT control groups are WT→WT mice given endotoxin alone in the second injection. There were no significant differences. B Shows a similar experiment in which disease was induced by IgG2b anti-TNP.