Table I.

Peripheral blood neutrophil counts two hours after disease induction

Data are shown for the experiments in which 15mg/kg IgG2a or IgG2b anti-TNP antibody, given 24 hours after TNP-conjugated nephrotoxic antibody, was given to mice as shown in figures 5, 6, 7 and 8. Peripheral blood neutrophil numbers were assessed at 2 hours after disease induction. The first three columns are from experiments in which IgG2a or IgG2b was given to knockout or wildtype mice. Values for wildtype (WT) mice from each experiment are shown in brackets beneath values for the knockout mice (mean±SEM) in each case. The fourth column shows data from experiments in which FcγRI ^-/→C3 ^-/- bone marrow chimeras were compared with WT→WT controls (the latter shown in brackets). The fifth column shows data from experiments in which mice given anti- FcγRIV blocking antibody were compared with control treated mice (shown in brackets). There were no significant differences in peripheral blood neutrophil counts at two hours in any of these experiments.

	FcγRIII -/- (WT)	FcγRI -/- (WT)	C3 -/- (WT)	FcγRI -/→C3 -/- chimeras (WT→WT)	anti-FcγRIV (control IgG)
IgG2a	266±115 (355±170)	340±69 (355±170)	169±29 (222±49)	337±87 (305±42)	179±30 (199±77)
IgG2b	425±100 (378±88)	346±39 (311±50)	443±48 (459±11)	181±21 (255±34)	187±47 (133±11)