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. Author manuscript; available in PMC: 2009 Mar 2.
Published in final edited form as: Neuropharmacology. 2008 Jul 16;56(1):285–291. doi: 10.1016/j.neuropharm.2008.07.009

Table 2.

[3H]granisetron binding affinities of wild type and mutant 5-HT3 receptors

Kd (nM) in 0 mM Ca2+ Kd (nM) in 10 mM Ca2+
Wild type 0.64 ± 0.08 (9) 1.93 ± 0.03 (4)*
E213Q 0.79 ± 0.21 (9) 0.61 ± 0.17 (5)
E215Q 0.41 ± 0.16 (7) 0.44 ± 0.08 (6)
E218Q NB (3) NB (3)
D204N 0.84 ± 0.17 (7) 0.76 ± 0.09 (5)
E277A/S297R 0.33 ± 0.04 (4) 0.68 ± 0.04 (4)*
V219L 0.82 ± 0.23 (6) 1.14 ± 0.34 (3)

Data = mean ± SEM, (n) NB = no binding.

*

Sig. dif. (P < 0.05) for the same mutant when compared at 0 and 10 mM external calcium.