Figure 1.

Comparison of amino acid sequences of mouse and human CA VBs and CA VAs. Fourteen amino acids conserved in mammalian CAs and thought to be near the active site are boxed. The proteolytic cleavage sites where the mitochondrial leader sequences are known or proposed to be cleaved are indicated by the triangles. The arginine at −2 positions from the cleavage sites are circled. The potential zinc-binding histidines equivalent to H94, H96, and H119 of CA I (2) are indicated by asterisks. The C-terminal peptides used to raise antibodies to mouse CA VB and CA VA are underlined.