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. 2009 Mar 6;4(3):e4725. doi: 10.1371/journal.pone.0004725

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Jansen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Serum hBD-2 protein levels of 15 patients for which PASI scores and serum was available on two different occasions over a 6–18 week interval, were plotted against the change in PASI score (ΔPASI). A significant linear correlation was found. Pearson R = 0.74, p<0.002. Note that there was a decrease in serum hBD-2 in most patients that showed clinical improvement (negative ΔPASI) and an increase in serum hBD-2 in a few patients that showed exacerbation (positive ΔPASI).