Figure 4.

Schematic representation of hair follicle formation from dissociated cells injected into mouse dermis. After injection of dissociated hair follicle progenitor cells (A), epidermal cell aggregates form (B). The small aggregate fuse to give rise to epidermal cysts (C), some of which fuse to form large cysts (D). Follicular outgrowths with associated follicular papillae initiate from the periphery of the cyst (E). The outgrowths are reminiscent of early follicle morphogenesis in the fetus (Fig. 1). The follicular outgrowths differentiate and eventually form protruding hair shafts (F).