Table 2.

The MicroRNA machinery and its association with human diseases

Disease	Gene	Mechanism	Literature
Fragile X Syndrome	Fmr1	recruits RISCs to specific mRNAs	Caudy et al.84; Jin et al.86
Spinal muscular atrophy	Gemini3 and 4	can bind to argonaute and associated with miRNAs	Dostie et al.92
DiGeorge syndrome	Dgcr8	partner of Drosha	Landthaler et al.93
Tourette's disease	Slitrk1	changes in miR-189 binding site of Slitrk1 gene	Abelson et al.94