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Corticotropin-releasing hormone (CRH)/urocortin (URC) signalling system regulates protective and homeostatic functions of the skin. CRH receptor (CRHR) type 1 (CRHR-1) is predominantly expressed in the epidermis, while both CRHR-1 and CRHR type 2 (CRHR-2) are expressed in the dermal or adnexal compartments.
